Matthias Zilbauer MD PhD MA MRCPCH

Matthias Zilbauer MD PhD MA MRCPCH

University Professor in Paediatric Gastroenterology, Hon. Consultant in Paediatric Gastroenterology, Principal Investigator, Wellcome-MRC Cambridge Stem Cell Institute

Biography: Matthias Zilbauer completed his medical training and obtained his MD degree from the University of Mainz, Germany and obtained a PhD in mucosal immunology from the Institute of Child Health at University College London (UCL, UK) investigating innate immunity of the intestinal epithelium. Matthias completed his clinical training in paediatrics as well as paediatric gastroenterology following training in several leading international centres based in the UK and Germany. In 2013, Matthias was appointed University Lecturer and Honorary Consultant in Paediatric Gastroenterology the University of Cambridge and Cambridge University Hospitals. Supported by an MRC New Investigator Research Award, Matthias established his research group with a focus on the role of epigenetic mechanisms in regulating intestinal epithelial stem-cell function in health, development, and Inflammatory Bowel Diseases. In 2022 Matthias joined the Cambridge Stem Cell Institute as a group leader. In 2023 he was named Clinical Professor of Paediatric Gastroenterology.

Key publications

  1. High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.
    Beumer J, Puschhof J, Bauzá-Martinez J, Martínez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, Artegiani B, Busslinger GA, Ponsioen B, Andersson-Rolf A, Saftien A, Boot C, Kretzschmar K, Geurts MH, Bar-Ephraim YE, Pleguezuelos-Manzano C, Post Y, Begthel H, van der Linden F, Lopez-Iglesias C, van de Wetering WJ, van der Linden R, Peters PJ, Heck AJR, Goedhart J, Snippert H, Zilbauer M, Teichmann SA, Wu W, Clevers H
    Cell. 2020 Aug 20;182(4):1062-1064. doi: 10.1016/j.cell.2020.08.005.
  2. APOBEC mutagenesis is a common process in normal human small intestine.
    Wang Y, Robinson PS, Coorens THH, Moore L, Lee-Six H, Noorani A, Sanders MA, Jung H, Katainen R, Heuschkel R, Brunton-Sim R, Weston R, Read D, Nobbs B, Fitzgerald RC, Saeb-Parsy K, Martincorena I, Campbell PJ, Rushbrook S, Zilbauer M, Buczacki SJA, Stratton MR
    Nat Genet. 2023 Feb;55(2):246-254.
  3. Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids.
    Edgar RD, Perrone F, Foster AR, Payne F, Lewis S, Nayak KM, Kraiczy J, Cenier A, Torrente F, Salvestrini C, Heuschkel R, Hensel KO, Harris R, Jones DL, Zerbino DR, Zilbauer M.
    Cell Mol Gastroenterol Hepatol. 2022;14(6):1295-1310. doi: 10.1016/j.jcmgh.2022.08.008. Epub 2022 Aug 28.
  4. Disease Prognostic Biomarkers in Inflammatory Bowel Diseases-A Reality Check
    Zilbauer M, Heuschkel R
    J Crohns Colitis. 2022 Jan 28;16(1):162-165.
  5. Cells of the human intestinal tract mapped across space and time.
    Elmentaite R, Kumasaka N, Roberts K, Fleming A, Dann E, King HW, Kleshchevnikov V, Dabrowska M, Pritchard S, Bolt L, Vieira SF, Mamanova L, Huang N, Perrone F, Goh Kai'En I, Lisgo SN, Katan M, Leonard S, Oliver TRW, Hook CE, Nayak K, Campos LS, Domínguez Conde C, Stephenson E, Engelbert J, Botting RA, Polanski K, van Dongen S, Patel M, Morgan MD, Marioni JC, Bayraktar OA, Meyer KB, He X, Barker RA, Uhlig HH, Mahbubani KT, Saeb-Parsy K, Zilbauer M, Clatworthy MR, Haniffa M, James KR, Teichmann SA
    Nature. 2021 Sep;597(7875):250-255. doi: 10.1038/s41586-021-03852-1. Epub 2021 Sep 8.
  6. Guidance on the interpretation of faecal calprotectin levels in children.
    Orfei M, Gasparetto M, Hensel KO, Zellweger F, Heuschkel RB, Zilbauer M
    PLoS One. 2021 Feb 11;16(2):e0246091.
  7. Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.
    Elmentaite R, Ross ADB, Roberts K, James KR, Ortmann D, Gomes T, Nayak K, Tuck L, Pritchard S, Bayraktar OA, Heuschkel R, Vallier L, Teichmann SA, Zilbauer M.
    Dev Cell. 2020 Dec 21;55(6):771-783.e5. doi: 10.1016/j.devcel.2020.11.010. Epub 2020 Dec 7.
  8. The growing gap between demand and availability of clinical psychology in Paediatric Gastroenterology: a retrospective analysis of clinical routine care.
    Wong E, Heuschkel R, Lindsay C, Benson S, Zilbauer M
    Eur J Pediatr. 2021 Apr;180(4):1307-1312.
  9. Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis.
    Gasparetto M, Payne F, Nayak K, Kraiczy J, Glemas C, Philip-McKenzie Y, Ross A, Edgar RD, Zerbino DR, Salvestrini C, Torrente F, Ventham NT, Kalla R, Satsangi J, Sarkies P, Heuschkel R, Zilbauer M.
    Gastroenterology. 2021 Jan;160(1):232-244.e7. doi: 10.1053/j.gastro.2020.08.017. Epub 2020 Aug 16.
  10. Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
    Serra EG, Schwerd T, Moutsianas L, Cavounidis A, Fachal L, Pandey S, Kammermeier J, Croft NM, Posovszky C, Rodrigues A, Russell RK, Barakat F, Auth MKH, Heuschkel R, Zilbauer M, Fyderek K, Braegger C, Travis SP, Satsangi J, Parkes M, Thapar N, Ferry H, Matte JC, Gilmour KC, Wedrychowicz A, Sullivan P, Moore C, Sambrook J, Ouwehand W, Roberts D, Danesh J, Baeumler TA, Fulga TA, Carrami EM, Ahmed A, Wilson R, Barrett JC, Elkadri A, Griffiths AM; COLORS in IBD group investigators; Oxford IBD cohort study investigators; INTERVAL Study; Swiss IBD cohort investigators; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium; Snapper SB, Shah N, Muise AM, Wilson DC, Uhlig HH, Anderson CA.
    Nat Commun. 2020 Feb 21;11(1):995.
  11. The landscape of somatic mutation in normal colorectal epithelial cells.
    Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O'Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR
    Nature. 2019 Oct;574(7779):532-537. doi: 10.1038/s41586-019-1672-7. Epub 2019 Oct 23.PMID: 31645730
  12. Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.
    Kraiczy J, Ross ADB, Forbester JL, Dougan G, Vallier L, Zilbauer M.
    Cell Mol Gastroenterol Hepatol. 2019;7(2):285-288. doi: 10.1016/j.jcmgh.2018.10.008. Epub 2018 Oct 23.
  13. Early Treatment Response Predicts Outcome in Paediatric Ulcerative Colitis: GASTROENTEROLOGY: INFLAMMATORY BOWEL DISEASE.
    Gasparetto M, Wong-Spracklen V, Torrente F, Howell K, Brennan M, Noble-Jamieson G, Heuschkel R, Zilbauer M.
    J Pediatr Gastroenterol Nutr. 2018 Aug;67(2):217-220.
  14. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.
    Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel PC, Stegle O, Dougan G, Heuschkel R, Koo BK, Zilbauer M
    Gut. 2019 Jan;68(1):49-61. doi: 10.1136/gutjnl-2017-314817. Epub 2017 Nov 15.
  15. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
    Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M
    Gastroenterology. 2018 Feb;154(3):585-598. doi: 10.1053/j.gastro.2017.10.007. Epub 2017 Oct
  16. Epigenetics in Paediatric Gastroenterology, Hepatology, and Nutrition: Present Trends and Future Perspectives.
    Zilbauer M, Zellos A, Heuschkel R, Gasparetto M, Kraiczy J, Postberg J, Greco L, Auricchio R, Galatola M, Embleton N, Wirth S, Jenke A
    J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):521-9
  17. Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy.
    Gasparetto M, Guariso G, Pozza LV, Ross A, Heuschkel R, Zilbauer M
    BMC Gastroenterol. 2016 Mar 15;16:35.
  18. Paediatric gastrointestinal endoscopy: a qualitative study.
    Wahid AM, Devarajan K, Ross A, Zilbauer M, Heuschkel R
    Eur J Gastroenterol Hepatol. 2016 Jan;28(1):25-9.
  19. Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease.
    Kraiczy J, Nayak K, Ross A, Raine T, Mak TN, Gasparetto M, Cario E, Rakyan V, Heuschkel R, Zilbauer M
    Mucosal Immunol. 2016 May;9(3):647-58
  20. Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases.
    Hensel KO, Boland V, Postberg J, Zilbauer M, Heuschkel R, Vogel S, Gödde D, Wirth S, Jenke AC
    Sci Rep. 2014 Dec 5;4:7343.
  21. Assessing quality of care in paediatric inflammatory bowel disease: focusing on self-reported outcomes.
    Gatti S, Brennan M, Heuschkel R, Zilbauer M
    Dig Liver Dis. 2015 Apr;47(4):347-8.
  22. Coeliac disease in children with type 1 diabetes: are current guidelines proving difficult to implement in practice?
    Atherton R, Ross A, Jessop F, Williams R, Heuschkel R, Zilbauer M
    J Pediatr Gastroenterol Nutr. 2014 Nov;59(5):600-3.
  23. Assessing quality outcome measures in children with coeliac disease--experience from two UK centres
    Ross A, Shelley H, Novell K, Ingham E, Callan J, Heuschkel R, Morris MA, Zilbauer M
    Nutrients. 2013 Nov 19;5(11):4605-13.
  24. Colitis-associated sclerosing cholangitis in children: a single centre experience.
    Noble-Jamieson G, Heuschkel RB, Torrente F, Hadzic N, Zilbauer M
    J Crohns Colitis. 2013 Nov;7(10): 414-8.
  25. Tissue transglutaminase antibody levels predict IgA deficiency.
    Shahnaz A, Maguire G, Parker R, Heuschkel RB, Zilbauer M
    Arch Dis Child. 2013 Nov;98(11):873-6.
  26. DNA methylation analysis in the intestinal epithelium-effect of cell separation on gene expression and methylation profile.
    Jenke AC, Postberg J, Raine T, Nayak KM, Molitor M, Wirth S, Kaser A, Parkes M, Heuschkel RB, Orth V, Zilbauer M
    PLoS One. 2013;8(2):e55636
  27. Use of small bowel MRI enteroclysis in the management of paediatric IBD.
    Sanka S, Gomez A, Set P, Rimareva N, Davies RJ, Rolfe P, Noble-Jamieson G, Torrente F, Heuschkel R, Zilbauer M
    J Crohns Colitis. 2012 Jun;6(5):550-6
  28. Intestinal alpha-defensin expression in pediatric inflammatory bowel disease.
    Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S
    Inflamm Bowel Dis. 2011 Oct;17(10):2076-86.
  29. Expression of human beta-defensins in children with chronic inflammatory bowel disease.
    Zilbauer M, Jenke A, Wenzel G, Postberg J, Heusch A, Phillips AD, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S
    PLoS One. 2010 Oct 22;5(10):e15389.